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Chemical structure of GSK1790627

GC69191

GSK1790627

Also known as 1-(3-aminophenyl)-3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7-trione

GSK1790627 is the N-deacetylated metabolite of Trametinib· Trametinib is an orally active MEK inhibitor that activates autophagy and induces cell apoptosis

ChemicalCAS871701-87-0MW573.36FormulaC24H21FIN5O3
CAS number
871701-87-0
Molecular weight
573.36
Formula
C24H21FIN5O3
Solubility
DMF ： 10 mg/mL (17·44 mM; Need ultrasonic)
InChIKey
JHOKCEWWVHBOFH-UHFFFAOYSA-N
Catalogue number
GC69191
Brand
GLPBIO
Computed properties PubChem CID 59717278 · XLogP 3.6 · TPSA 99 Ų · H-bond donors 2
XLogP
3.6
TPSA
99 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
34

SMILES CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)N)C5CC5

Computed descriptors from PubChem (CID 59717278), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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