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Chemical structure of GSK180736A

GC19177

GSK180736A

Also known as 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide

GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0·77 uM

ChemicalCAS817194-38-0MW365.36FormulaC19H16FN5O2
CAS number
817194-38-0
Molecular weight
365.36
Formula
C19H16FN5O2
Solubility
DMSO : ≥ 30 mg/mL (82·11 mM)
InChIKey
HEAIGWIZTYAQTC-UHFFFAOYSA-N
Catalogue number
GC19177
Brand
GLPBIO
Computed properties PubChem CID 11233873 · XLogP 1.7 · TPSA 98.9 Ų · H-bond donors 4
XLogP
1.7
TPSA
98.9 Ų
H-bond donors
4
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
27

SMILES CC1=C(C(NC(=O)N1)C2=CC=C(C=C2)F)C(=O)NC3=CC4=C(C=C3)NN=C4

Computed descriptors from PubChem (CID 11233873), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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