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Chemical structure of Tivumecirnon

GC69120

Tivumecirnon

Also known as 2-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-(trifluoromethyl)pyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]ethanol

Tivumecirnon (FLX475) is an effective CCR4 antagonist that can block regulatory T cells that interfere with effective anti-tumor immune responses, and has anti-tumor activity

ChemicalCAS2174938-78-2MW543.41FormulaC24H27Cl2F3N6O
CAS number
2174938-78-2
Molecular weight
543.41
Formula
C24H27Cl2F3N6O
Solubility
DMSO ： 100 mg/mL (184·02 mM; Need ultrasonic)
InChIKey
AKSVALRPYDVQBS-CABCVRRESA-N
Catalogue number
GC69120
Brand
GLPBIO
Computed properties PubChem CID 134210715 · XLogP 4.6 · TPSA 70.3 Ų · H-bond donors 1
XLogP
4.6
TPSA
70.3 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
6
Heavy atoms
36

SMILES C[C@H](C1=C(C=C(C=C1)Cl)Cl)N2C3=NC(=CN=C3C(=N2)C(F)(F)F)N4CC(C4)[C@H]5CCCN(C5)CCO

Computed descriptors from PubChem (CID 134210715), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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