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Chemical structure of EIF2α activator 1

GC69046

EIF2α activator 1

Also known as 3-[[3,4-dioxo-2-[[4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]cyclobuten-1-yl]amino]-5-(trifluoromethyl)benzonitrile

EIF2α activator 1 (Compound 40) is an activator of eukaryotic initiation factor 2α (eIF2α) phosphorylation· EIF2α activator 1 increases the expression levels of downstream proteins ATF and CHOP· EIF2α activator 1 has anti-proliferative activity against K562 and PBMC cells, with IC50 values of 4·00 and 19·3 μM, respectively

ChemicalCAS2851820-52-3MW523.43FormulaC25H19F6N3O3
CAS number
2851820-52-3
Molecular weight
523.43
Formula
C25H19F6N3O3
InChIKey
PYDUAMACJGQTQN-UHFFFAOYSA-N
Catalogue number
GC69046
Brand
GLPBIO
Computed properties PubChem CID 164517084 · XLogP 6 · TPSA 91.2 Ų · H-bond donors 2
XLogP
6
TPSA
91.2 Ų
H-bond donors
2
H-bond acceptors
12
Rotatable bonds
6
Heavy atoms
37

SMILES C1CC(CCC1NC2=C(C(=O)C2=O)NC3=CC(=CC(=C3)C(F)(F)F)C#N)OC4=CC=C(C=C4)C(F)(F)F

Computed descriptors from PubChem (CID 164517084), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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