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Chemical structure of Dyrk1A-IN-5

GC69031

Dyrk1A-IN-5

Also known as 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid

Dyrk1A-IN-5 (compound 5j) is a potent and selective inhibitor of DYRK1A with an IC50 value of 6 nM· Dyrk1A-IN-5 dose-dependently reduces the phosphorylation of Thr434 in SF3B1, with an IC50 of 0·5 μM· Dyrk1A-IN-5 inhibits the phosphorylation of tau protein at Thr212, with an IC50 of 2·1 μM· Dyrk1A-IN-5 can be used for research on Down syndrome

ChemicalCAS1685235-41-9MW388.16FormulaC16H9IN2O2
CAS number
1685235-41-9
Molecular weight
388.16
Formula
C16H9IN2O2
Solubility
DMSO ： 3·33 mg/mL (8·58 mM; ultrasonic and warming and heat to 160°C)
InChIKey
SDRAETFVRBBLOB-UHFFFAOYSA-N
Catalogue number
GC69031
Brand
GLPBIO
Computed properties PubChem CID 91664021 · XLogP 4.2 · TPSA 66 Ų · H-bond donors 2
XLogP
4.2
TPSA
66 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
1
Heavy atoms
21

SMILES C1=CC=C2C(=C1)C3=C(C4=C(N3)C(=CC=C4)I)C(=N2)C(=O)O

Computed descriptors from PubChem (CID 91664021), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.