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Chemical structure of Cofrogliptin

GC68890

Cofrogliptin

Also known as (2R,3S,5R,6S)-2-(2,5-difluorophenyl)-5-(2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-6-(trifluoromethyl)oxan-3-amine

Cofrogliptin (HSK7653) (compound 2), a tetrahydrofuran derivative, is an effective oral DPP-4 inhibitor with long-lasting blood sugar-lowering effects· Cofrogliptin (compound 2) has great potential in the treatment of type 2 diabetes mellitus (T2DM)

ChemicalCAS1844874-26-5MW466.43FormulaC18H19F5N4O3S
CAS number
1844874-26-5
Molecular weight
466.43
Formula
C18H19F5N4O3S
Solubility
DMSO ： 100 mg/mL (214·39 mM; Need ultrasonic)
InChIKey
GUBOXFWNNXSQNH-SVGFKBNWSA-N
Catalogue number
GC68890
Brand
GLPBIO
Computed properties PubChem CID 118613788 · XLogP 1.4 · TPSA 98.8 Ų · H-bond donors 1
XLogP
1.4
TPSA
98.8 Ų
H-bond donors
1
H-bond acceptors
11
Rotatable bonds
3
Heavy atoms
31

SMILES CS(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](O[C@@H]3C(F)(F)F)C4=C(C=CC(=C4)F)F)N

Computed descriptors from PubChem (CID 118613788), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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