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Chemical structure of BRD0209

GC68802

BRD0209

Also known as (4S)-3-cyclopropyl-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one

BRD0209 is an effective, selective, and dual inhibitor of GSK3α/β (GSK3α IC50 = 19 nM; GSK3β IC50 = 5 nM)· It is also a reversible ATP-competitive inhibitor with fast kinetics (Ki values of 4·2 nM for both isoforms)· BRD0209 is a tricyclic pyrazolone-fused tetrahydroquinoline compound· It has potential in researching mood disorders

ChemicalCAS1597439-87-6MW347.45FormulaC22H25N3O
CAS number
1597439-87-6
Molecular weight
347.45
Formula
C22H25N3O
Solubility
DMSO ： 62·5 mg/mL (179·88 mM; Need ultrasonic)
InChIKey
YKPIWOGXCSQLFH-JOCHJYFZSA-N
Catalogue number
GC68802
Brand
GLPBIO
Computed properties PubChem CID 135567204 · XLogP 4.2 · TPSA 57.8 Ų · H-bond donors 2
XLogP
4.2
TPSA
57.8 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
2
Heavy atoms
26

SMILES C[C@]1(C2=C(CC(CC2=O)(C)C)NC3=NNC(=C31)C4CC4)C5=CC=CC=C5

Computed descriptors from PubChem (CID 135567204), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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