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Chemical structure of AT-533

GC68703

AT-533

Also known as 2-[(4-hydroxycyclohexyl)amino]-4-(3,6,6-trimethyl-4-oxo-5,7-dihydroindazol-1-yl)benzamide

AT-533 is an effective inhibitor of Hsp90 and HSV· It inhibits tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway· AT-533 also inhibits downstream pathway activation, including Akt/mTOR/p70S6K, Erk1/2, and FAK· AT-533 suppresses tube formation, cell migration, and invasion in human umbilical vein endothelial cells (HUVEC)

ChemicalCAS908112-37-8MW410.51FormulaC23H30N4O3
CAS number
908112-37-8
Molecular weight
410.51
Formula
C23H30N4O3
Solubility
DMSO ： 33·33 mg/mL (81·19 mM; ultrasonic and warming and heat to 60°C)
InChIKey
FMOSGTTYAFQMSD-UHFFFAOYSA-N
Catalogue number
GC68703
Brand
GLPBIO
Computed properties PubChem CID 24820800 · XLogP 3.3 · TPSA 110 Ų · H-bond donors 3
XLogP
3.3
TPSA
110 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
30

SMILES CC1=NN(C2=C1C(=O)CC(C2)(C)C)C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O

Computed descriptors from PubChem (CID 24820800), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.