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Chemical structure of AGN 192870

GC68629

AGN 192870

Also known as 4-[2-(5,5-dimethyl-8-phenyl-6H-naphthalen-2-yl)ethynyl]benzoic acid

AGN 192870 is a RAR neutral antagonist with Kd values of 147, 33, and 42 nM for RARα, RARβ, and RARγ respectively· The IC50 values for AGN 192870 are 87 and 32 nM for RARα and RARγ respectively· AGN 192870 exhibits partial agonistic activity on RARβ

ChemicalCAS166977-57-7MW378.46FormulaC27H22O2
CAS number
166977-57-7
Molecular weight
378.46
Formula
C27H22O2
Solubility
DMSO ： 6·25 mg/mL (16·51 mM; ultrasonic and warming and heat to 60°C)
InChIKey
LTHJFFPLLKIZTC-UHFFFAOYSA-N
Catalogue number
GC68629
Brand
GLPBIO
Computed properties PubChem CID 10339622 · XLogP 6.6 · TPSA 37.3 Ų · H-bond donors 1
XLogP
6.6
TPSA
37.3 Ų
H-bond donors
1
H-bond acceptors
2
Rotatable bonds
4
Heavy atoms
29

SMILES CC1(CC=C(C2=C1C=CC(=C2)C#CC3=CC=C(C=C3)C(=O)O)C4=CC=CC=C4)C

Computed descriptors from PubChem (CID 10339622), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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