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Chemical structure of Claficapavir

GC66467

Claficapavir

Also known as 3-[(5Z)-5-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid

Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM· Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1

ChemicalCAS2055732-24-4MW393.86FormulaC17H12ClNO4S2
CAS number
2055732-24-4
Molecular weight
393.86
Formula
C17H12ClNO4S2
Solubility
DMSO ： 200 mg/mL (507·79 mM; ultrasonic and warming and heat to 40°C)
InChIKey
YZLFZFALAZYTCI-ZROIWOOFSA-N
Catalogue number
GC66467
Brand
GLPBIO
Computed properties PubChem CID 1286537 · XLogP 3.9 · TPSA 128 Ų · H-bond donors 1
XLogP
3.9
TPSA
128 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
25

SMILES C1=CC(=CC=C1C2=CC=C(O2)/C=C\3/C(=O)N(C(=S)S3)CCC(=O)O)Cl

Computed descriptors from PubChem (CID 1286537), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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