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Chemical structure of Ro 41-5253

GC66433

Ro 41-5253

Also known as 4-[(E)-2-(7-heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)prop-1-enyl]benzoic acid

Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist· Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding· Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity

ChemicalCAS144092-31-9MW484.65FormulaC28H36O5S
CAS number
144092-31-9
Molecular weight
484.65
Formula
C28H36O5S
InChIKey
JEIWQRITHXYGIF-LVZFUZTISA-N
Catalogue number
GC66433
Brand
GLPBIO
Computed properties PubChem CID 5312120 · XLogP 7.7 · TPSA 89.1 Ų · H-bond donors 1
XLogP
7.7
TPSA
89.1 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
10
Heavy atoms
34

SMILES CCCCCCCOC1=CC2=C(C=C1/C(=C/C3=CC=C(C=C3)C(=O)O)/C)C(CCS2(=O)=O)(C)C

Computed descriptors from PubChem (CID 5312120), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.