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Chemical structure of Ro 46-8443

GC63837

Ro 46-8443

Also known as 4-tert-butyl-N-[6-[(2R)-2,3-dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl]benzenesulfonamide

Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist

ChemicalCAS175556-12-4MW609.69FormulaC31H35N3O8S
CAS number
175556-12-4
Molecular weight
609.69
Formula
C31H35N3O8S
Solubility
DMSO ： 250 mg/mL (410·04 mM; Need ultrasonic)
InChIKey
DRIHNVYRUGBDHI-JOCHJYFZSA-N
Catalogue number
GC63837
Brand
GLPBIO
Computed properties PubChem CID 5312146 · XLogP 4.9 · TPSA 158 Ų · H-bond donors 3
XLogP
4.9
TPSA
158 Ų
H-bond donors
3
H-bond acceptors
11
Rotatable bonds
13
Heavy atoms
43

SMILES CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=CC=C(C=C3)OC)OC[C@@H](CO)O)OC4=CC=CC=C4OC

Computed descriptors from PubChem (CID 5312146), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.