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Chemical structure of Zapalog

GC66370

Zapalog

Also known as [(1R)-1-[3-[4-[4-[1-[2-[4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenoxy]ethoxy]ethyl]-2-methoxy-5-nitrophenoxy]butanoylamino]phenyl]-3-(3,4-dimethoxyphenyl)propyl] (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins· Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis

ChemicalCAS1708091-24-0MW1108.24FormulaC58H73N7O15
CAS number
1708091-24-0
Molecular weight
1108.24
Formula
C58H73N7O15
Solubility
DMSO ： 100 mg/mL (90·23 mM; Need ultrasonic)
InChIKey
ONSMHWXTRWDIMR-SXIGHEGWSA-N
Catalogue number
GC66370
Brand
GLPBIO
Computed properties PubChem CID 118048999 · XLogP 8.1 · TPSA 290 Ų · H-bond donors 3
XLogP
8.1
TPSA
290 Ų
H-bond donors
3
H-bond acceptors
19
Rotatable bonds
29
Heavy atoms
80

SMILES CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)NC(=O)CCCOC4=C(C=C(C(=C4)[N+](=O)[O-])C(C)OCCOC5=C(C=C(C=C5OC)CC6=CN=C(N=C6N)N)OC)OC

Computed descriptors from PubChem (CID 118048999), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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