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Chemical structure of δ-Secretase inhibitor 11

GC66048

δ-Secretase inhibitor 11

Also known as 4-morpholin-4-yl-2,1,3-benzoxadiazol-7-amine

δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0·7 μM· δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase· δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage· δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models· δ-Secretase inhibitor 11 can be used for Alzheimer's disease research

ChemicalCAS842964-18-5MW220.23FormulaC10H12N4O2
CAS number
842964-18-5
Molecular weight
220.23
Formula
C10H12N4O2
Solubility
DMSO ： 125 mg/mL (567·59 mM; Need ultrasonic)
InChIKey
LWCSTSZSZFUHAT-UHFFFAOYSA-N
Catalogue number
GC66048
Brand
GLPBIO
Computed properties PubChem CID 1095027 · XLogP 0.2 · TPSA 77.4 Ų · H-bond donors 1
XLogP
0.2
TPSA
77.4 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
1
Heavy atoms
16

SMILES C1COCCN1C2=CC=C(C3=NON=C23)N

Computed descriptors from PubChem (CID 1095027), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.