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Chemical structure of SKI-I

GC66011

SKI-I

Also known as N-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]-3-naphthalen-2-yl-1H-pyrazole-5-carboxamide

SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1·2 μM for ST-hSK· SKI-I also inhibits hERK2 (IC50=11 μM)· SKI-I induces apoptosis in tumor cell lines

ChemicalCAS306301-68-8MW406.44FormulaC25H18N4O2
CAS number
306301-68-8
Molecular weight
406.44
Formula
C25H18N4O2
Solubility
DMSO ： 100 mg/mL (246·04 mM; Need ultrasonic)
InChIKey
XOXCTLAKMCIWCF-CVKSISIWSA-N
Catalogue number
GC66011
Brand
GLPBIO
Computed properties PubChem CID 135515522 · XLogP 5.3 · TPSA 90.4 Ų · H-bond donors 3
XLogP
5.3
TPSA
90.4 Ų
H-bond donors
3
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
31

SMILES C1=CC=C2C=C(C=CC2=C1)C3=NNC(=C3)C(=O)N/N=C/C4=C(C=CC5=CC=CC=C54)O

Computed descriptors from PubChem (CID 135515522), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.