GC65969
CHMFL-PI3KD-317
Also known as (2S)-2-amino-N-[5-[6-chloro-5-[(3-methylphenyl)sulfonylamino]-3-pyridinyl]-4-methyl-1,3-thiazol-2-yl]-3-methylbutanamide
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, 62·6 nM), PI3Kβ (IC50, 284 nM), PI3Kγ (IC50, 202·7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882·3 nM), VPS34 (IC50, 1801·7 nM), PI4KIIIA (IC50, 574·1 nM) and PI4KIIIB (IC50, 300·2 nM)· CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4·3 nM· CHMFL-PI3KD-317 has antiproliferative effects on cancer cells
- CAS number
- 2244992-76-3
- Molecular weight
- 494.03
- Formula
- C21H24ClN5O3S2
- InChIKey
- PIBKKQFQADCDAW-KRWDZBQOSA-N
- Catalogue number
- GC65969
- Brand
- GLPBIO
Computed properties PubChem CID 137333450 · XLogP 3.8 · TPSA 164 Ų · H-bond donors 3
- XLogP
- 3.8
- TPSA
- 164 Ų
- H-bond donors
- 3
- H-bond acceptors
- 8
- Rotatable bonds
- 7
- Heavy atoms
- 32
SMILES CC1=CC(=CC=C1)S(=O)(=O)NC2=C(N=CC(=C2)C3=C(N=C(S3)NC(=O)[C@H](C(C)C)N)C)Cl
Computed descriptors from PubChem (CID 137333450), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il