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Chemical structure of Dot1L-IN-5

GC65962

Dot1L-IN-5

Also known as 3-[(4-amino-6-methoxy-1,3,5-triazin-2-yl)amino]-4-[[(S)-(3-chloro-2-pyridinyl)-(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]amino]benzenesulfonamide

Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0·17 nM

ChemicalCAS2565705-03-3MW592.96FormulaC23H19ClF2N8O5S
CAS number
2565705-03-3
Molecular weight
592.96
Formula
C23H19ClF2N8O5S
Solubility
DMSO ： 250 mg/mL (421·61 mM; Need ultrasonic)
InChIKey
BAQOPDGRUNKWLM-KRWDZBQOSA-N
Catalogue number
GC65962
Brand
GLPBIO
Computed properties PubChem CID 145704696 · XLogP 3.7 · TPSA 198 Ų · H-bond donors 4
XLogP
3.7
TPSA
198 Ų
H-bond donors
4
H-bond acceptors
15
Rotatable bonds
8
Heavy atoms
40

SMILES COC1=NC(=NC(=N1)NC2=C(C=CC(=C2)S(=O)(=O)N)N[C@@H](C3=C4C(=CC=C3)OC(O4)(F)F)C5=C(C=CC=N5)Cl)N

Computed descriptors from PubChem (CID 145704696), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.