Loading...
Chemical structure of HS-276

GC65941

HS-276

Also known as 3-N-[6-(piperidin-1-ylmethyl)-1-propylbenzimidazol-2-yl]benzene-1,3-dicarboxamide

HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2·5 nM· HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8·25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively· HS-276 can be used for rheumatoid arthritis (RA) research

ChemicalCAS2767422-72-8MW419.52FormulaC24H29N5O2
CAS number
2767422-72-8
Molecular weight
419.52
Formula
C24H29N5O2
Solubility
DMSO ： 50 mg/mL (119·18 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 80°C)
InChIKey
NPEMHKSMWPZEOV-UHFFFAOYSA-N
Catalogue number
GC65941
Brand
GLPBIO
Computed properties PubChem CID 164517032 · XLogP 3 · TPSA 93.3 Ų · H-bond donors 2
XLogP
3
TPSA
93.3 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
7
Heavy atoms
31

SMILES CCCN1C2=C(C=CC(=C2)CN3CCCCC3)N=C1NC(=O)C4=CC=CC(=C4)C(=O)N

Computed descriptors from PubChem (CID 164517032), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.