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Chemical structure of HS-27

GC61784

HS-27

Also known as 2-[3-[2-[2-[2-[2-[3-[(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)carbamothioylamino]propoxy]ethoxy]ethoxy]ethoxy]ethoxy]propylamino]-4-(3,6,6-trimethyl-4-oxo-5,7-dihydroindazol-1-yl)benzamide

HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens· HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90· HS-27 has potential use in a see-and-treat paradigm in breast cancer

ChemicalCAS1562024-11-6MW993.13FormulaC52H60N6O12S
CAS number
1562024-11-6
Molecular weight
993.13
Formula
C52H60N6O12S
Solubility
DMSO： 125 mg/mL (125·86 mM)
InChIKey
QUGHMMYGFASWKI-UHFFFAOYSA-N
Catalogue number
GC61784
Brand
GLPBIO
Computed properties PubChem CID 72943314 · XLogP 5.4 · TPSA 268 Ų · H-bond donors 6
XLogP
5.4
TPSA
268 Ų
H-bond donors
6
H-bond acceptors
15
Rotatable bonds
24
Heavy atoms
71

SMILES CC1=NN(C2=C1C(=O)CC(C2)(C)C)C3=CC(=C(C=C3)C(=O)N)NCCCOCCOCCOCCOCCOCCCNC(=S)NC4=CC5=C(C=C4)C6(C7=C(C=C(C=C7)O)OC8=C6C=CC(=C8)O)OC5=O

Computed descriptors from PubChem (CID 72943314), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.