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Chemical structure of Glucosylceramide synthase-IN-2

GC65902

Glucosylceramide synthase-IN-2

Also known as N-[4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]pyridazine-4-carboxamide

Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively·Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose·Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research

ChemicalCAS2597958-02-4MW447.41FormulaC22H20F3N3O4
CAS number
2597958-02-4
Molecular weight
447.41
Formula
C22H20F3N3O4
Solubility
DMSO ： 100 mg/mL (223·51 mM; Need ultrasonic)
InChIKey
CQAPXPSWLDAVEG-UHFFFAOYSA-N
Catalogue number
GC65902
Brand
GLPBIO
Computed properties PubChem CID 155595153 · XLogP 2.9 · TPSA 91.2 Ų · H-bond donors 2
XLogP
2.9
TPSA
91.2 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
32

SMILES CC(C)(C1=CC=C(C=C1)NC(=O)C2=CC=NN(C2=O)C3=CC=CC=C3OCC(F)(F)F)O

Computed descriptors from PubChem (CID 155595153), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.