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Chemical structure of ADAMTS-5-IN-3

GC65900

ADAMTS-5-IN-3

Also known as (5S)-5-cyclopropyl-5-[3-[(5R)-7,8-dichloro-5-methyl-1,2,4,5-tetrahydro-3-benzazepin-3-yl]-3-oxopropyl]imidazolidine-2,4-dione

ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively· ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis

ChemicalCAS2688733-96-0MW424.32FormulaC20H23Cl2N3O3
CAS number
2688733-96-0
Molecular weight
424.32
Formula
C20H23Cl2N3O3
Solubility
DMSO ： 200 mg/mL (471·34 mM; Need ultrasonic)
InChIKey
LBFZDWQGADLLKS-YBTHPKLGSA-N
Catalogue number
GC65900
Brand
GLPBIO
Computed properties PubChem CID 163196430 · XLogP 2.9 · TPSA 78.5 Ų · H-bond donors 2
XLogP
2.9
TPSA
78.5 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
4
Heavy atoms
28

SMILES C[C@H]1CN(CCC2=CC(=C(C=C12)Cl)Cl)C(=O)CC[C@@]3(C(=O)NC(=O)N3)C4CC4

Computed descriptors from PubChem (CID 163196430), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.