GC65883
(S,R)-WT IDH1 Inhibitor 2
Also known as (7S)-1-[(4-fluorophenyl)methyl]-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrole-2-carbonyl)-6,7-dihydro-4H-pyrazolo[4,5-c]pyridine-3-carboxamide
(S,R)-WT IDH1 Inhibitor 2 (GSK321) is a potent, selective mutant IDH1 inhibitor with IC50 values of 2·9, 3·8, 4·6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2· (S,R)-WT IDH1 Inhibitor 2 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells· (S,R)-WT IDH1 Inhibitor 2 can be used for research of acute myeloid leukemia (AML) and other cancers
- CAS number
- 1816272-18-0
- Molecular weight
- 501.55
- Formula
- C28H28FN5O3
- InChIKey
- IVFDDVKCCBDPQZ-ZWKOTPCHSA-N
- Catalogue number
- GC65883
- Brand
- GLPBIO
Computed properties PubChem CID 165412569 · XLogP 3.1 · TPSA 103 Ų · H-bond donors 3
- XLogP
- 3.1
- TPSA
- 103 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Rotatable bonds
- 6
- Heavy atoms
- 37
SMILES C[C@H]1CN(CC2=C1N(N=C2C(=O)NC3=CC=CC(=C3)[C@@H](C)O)CC4=CC=C(C=C4)F)C(=O)C5=CC=CN5
Computed descriptors from PubChem (CID 165412569), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il