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Chemical structure of PROTAC EZH2 Degrader-1

GC65509

PROTAC EZH2 Degrader-1

Also known as N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-[4-[[4-[7-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyheptyl]piperazin-1-yl]methyl]phenyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide

PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2·7 nM· EZH2 plays an important role in many tumorigenesis and development processes

ChemicalCAS2641601-67-2MW942.15FormulaC54H67N7O8
CAS number
2641601-67-2
Molecular weight
942.15
Formula
C54H67N7O8
Solubility
DMSO ： 160 mg/mL (169·82 mM; Need ultrasonic)
InChIKey
LONVYJSHGSZBQY-UHFFFAOYSA-N
Catalogue number
GC65509
Brand
GLPBIO
Computed properties PubChem CID 156351362 · XLogP 6.2 · TPSA 170 Ų · H-bond donors 3
XLogP
6.2
TPSA
170 Ų
H-bond donors
3
H-bond acceptors
11
Rotatable bonds
19
Heavy atoms
69

SMILES CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCN(CC5)CCCCCCCOC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O

Computed descriptors from PubChem (CID 156351362), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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