GC65506
BETd-246
Also known as 4-[(3-cyclopropyl-1-ethylpyrazol-5-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[3-[2-[2-[3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]propoxy]ethoxy]ethoxy]propyl]-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide
BETd-246 is a second-generation and PROTAC-based BET bromodomain (BRD) inhibitor connected by ligands for Cereblon and BET, exhibiting superior selectivity, potency and antitumor activity
ChemicalCAS2140289-17-2MW946.02FormulaC48H55N11O10
- CAS number
- 2140289-17-2
- Molecular weight
- 946.02
- Formula
- C48H55N11O10
- Solubility
- DMSO ： 200 mg/mL (211·41 mM; Need ultrasonic)
- InChIKey
- XEJMFVWHCPNMRS-UHFFFAOYSA-N
- Catalogue number
- GC65506
- Brand
- GLPBIO
Computed properties PubChem CID 131698640 · XLogP 4.6 · TPSA 259 Ų · H-bond donors 5
- XLogP
- 4.6
- TPSA
- 259 Ų
- H-bond donors
- 5
- H-bond acceptors
- 16
- Rotatable bonds
- 23
- Heavy atoms
- 69
SMILES CCN1C(=CC(=N1)C2CC2)NC3=NC(=NC4=C3C5=CC(=C(C=C5N4)C6=C(ON=C6C)C)OC)C(=O)NCCCOCCOCCOCCCNC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O
Computed descriptors from PubChem (CID 131698640), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il