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Chemical structure of BETd-260 (ZBC 260)

GC32791

BETd-260 (ZBC 260)

Also known as 4-[(3-cyclopropyl-1-ethylpyrazol-5-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[5-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]pentyl]-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide

BETd-260 (ZBC 260) (ZBC 260) is a PROTAC connected by ligands for Cereblon and BET, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line· BETd-260 (ZBC 260) potently suppresses cell viability and robustly induces apoptosis in hepatocellular carcinoma (HCC) cells

ChemicalCAS2093388-62-4MW798.89FormulaC43H46N10O6
CAS number
2093388-62-4
Molecular weight
798.89
Formula
C43H46N10O6
Solubility
DMSO ： 25 mg/mL (31·29 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
UZXANFBIRSYHGO-UHFFFAOYSA-N
Catalogue number
GC32791
Brand
GLPBIO
Computed properties PubChem CID 131698639 · XLogP 5.3 · TPSA 202 Ų · H-bond donors 4
XLogP
5.3
TPSA
202 Ų
H-bond donors
4
H-bond acceptors
11
Rotatable bonds
14
Heavy atoms
59

SMILES CCN1C(=CC(=N1)C2CC2)NC3=NC(=NC4=C3C5=CC(=C(C=C5N4)C6=C(ON=C6C)C)OC)C(=O)NCCCCCC7=C8CN(C(=O)C8=CC=C7)C9CCC(=O)NC9=O

Computed descriptors from PubChem (CID 131698639), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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