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Chemical structure of Homo-PROTAC pVHL30 degrader 1

GC65285

Homo-PROTAC pVHL30 degrader 1

Also known as (2S,4R)-4-hydroxy-1-[(2S)-2-[[2-[2-[2-[2-[2-[2-[2-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-2-oxoethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC, consists of two ligands of von Hippel-Lindau

ChemicalCAS2244684-49-7MW1179.45FormulaC58H82N8O14S2
CAS number
2244684-49-7
Molecular weight
1179.45
Formula
C58H82N8O14S2
Solubility
DMSO ： ≥ 150 mg/mL (127·18 mM)
InChIKey
WGJCHHJGGFCCRS-DEYDLUNASA-N
Catalogue number
GC65285
Brand
GLPBIO
Computed properties PubChem CID 134160242 · XLogP 3.6 · TPSA 335 Ų · H-bond donors 6
XLogP
3.6
TPSA
335 Ų
H-bond donors
6
H-bond acceptors
18
Rotatable bonds
33
Heavy atoms
82

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@@H](C[C@H]4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)O

Computed descriptors from PubChem (CID 134160242), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.