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Chemical structure of Homo-PROTAC cereblon degrader 1

GC33391

Homo-PROTAC cereblon degrader 1

Also known as 2-(2,6-dioxopiperidin-3-yl)-4-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethylamino]isoindole-1,3-dione

Homo-PROTAC cereblon degrader 1 (compound 15a) is a highly potent and efficient Cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3

ChemicalCAS2244520-98-5MW660.63FormulaC32H32N6O10
CAS number
2244520-98-5
Molecular weight
660.63
Formula
C32H32N6O10
Solubility
DMSO： 200 mg/mL (302·74 mM)
InChIKey
OXIPFLHBDVDLDS-UHFFFAOYSA-N
Catalogue number
GC33391
Brand
GLPBIO
Computed properties PubChem CID 137628659 · XLogP 0.8 · TPSA 210 Ų · H-bond donors 4
XLogP
0.8
TPSA
210 Ų
H-bond donors
4
H-bond acceptors
12
Rotatable bonds
13
Heavy atoms
48

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O

Computed descriptors from PubChem (CID 137628659), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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