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Chemical structure of PROTAC PARP1 degrader

GC65147

PROTAC PARP1 degrader

Also known as 2-[4-[1-[2-[2-[2-[2-[2-[[2-[4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-2-oxopiperazin-1-yl]acetyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]phenyl]indazole-7-carboxamide

PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand· It induces significant PARP1 cleavage and programmed cell death· PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6·12 μM

ChemicalCAS2369022-68-2MW1145.09FormulaC58H63Cl2N11O10
CAS number
2369022-68-2
Molecular weight
1145.09
Formula
C58H63Cl2N11O10
InChIKey
RQWKTYKJNCZUJW-OMUYKDLESA-N
Catalogue number
GC65147
Brand
GLPBIO
Computed properties PubChem CID 138454769 · XLogP 5.4 · TPSA 232 Ų · H-bond donors 2
XLogP
5.4
TPSA
232 Ų
H-bond donors
2
H-bond acceptors
14
Rotatable bonds
26
Heavy atoms
81

SMILES CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@@H]([C@@H](N2C(=O)N3CCN(C(=O)C3)CC(=O)NCCOCCOCCOCCOCCN4C=C(N=N4)C5=CC=C(C=C5)N6C=C7C=CC=C(C7=N6)C(=O)N)C8=CC=C(C=C8)Cl)C9=CC=C(C=C9)Cl

Computed descriptors from PubChem (CID 138454769), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.