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Chemical structure of TRi-1

GC65101

TRi-1

Also known as 2-(4-chlorophenyl)sulfonyl-6-methoxy-3-nitropyridine

TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM· TRi-1 has little mitochondrial toxicity for anticancer therapy

ChemicalCAS246020-68-8MW328.73FormulaC12H9ClN2O5S
CAS number
246020-68-8
Molecular weight
328.73
Formula
C12H9ClN2O5S
Solubility
DMSO ： 62·5 mg/mL (190·13 mM; Need ultrasonic)
InChIKey
PRKWNRUVAZZHPH-UHFFFAOYSA-N
Catalogue number
GC65101
Brand
GLPBIO
Computed properties PubChem CID 2801235 · XLogP 2.7 · TPSA 110 Ų · H-bond donors 0
XLogP
2.7
TPSA
110 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
3
Heavy atoms
21

SMILES COC1=NC(=C(C=C1)[N+](=O)[O-])S(=O)(=O)C2=CC=C(C=C2)Cl

Computed descriptors from PubChem (CID 2801235), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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