Loading...
Chemical structure of MS4322

GC65052

MS4322

Also known as N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-6-[[1-[2-[2-[2-[2-[2-[2-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-2-oxoethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]azetidin-3-yl]amino]pyrimidine-4-carboxamide

MS4322 (YS43-22) is a first-in-class PRMT5 degrader and a valuable chemical tool (PROTAC) for exploring the PRMT5 functions in health and disease

ChemicalCAS2375432-47-4MW1101.32FormulaC55H76N10O12S
CAS number
2375432-47-4
Molecular weight
1101.32
Formula
C55H76N10O12S
Solubility
DMSO ： 100 mg/mL (90·80 mM; Need ultrasonic)
InChIKey
XUJMNOQMXWVXQE-STHBVIMFSA-N
Catalogue number
GC65052
Brand
GLPBIO
Computed properties PubChem CID 162652211 · XLogP 2.2 · TPSA 297 Ų · H-bond donors 6
XLogP
2.2
TPSA
297 Ų
H-bond donors
6
H-bond acceptors
18
Rotatable bonds
30
Heavy atoms
78

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOCCOCCOCC(=O)N4CC(C4)NC5=NC=NC(=C5)C(=O)NC[C@@H](CN6CCC7=CC=CC=C7C6)O)O

Computed descriptors from PubChem (CID 162652211), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.