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Chemical structure of WS-383

GC64975

WS-383

Also known as 2-[5-[[2-[(4-chlorophenyl)methylsulfanyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]sulfanyl]tetrazol-1-yl]-N,N-dimethylethanamine;hydrochloride

WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM· WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2

ChemicalCAS2247544-02-9MW498.46FormulaC18H21Cl2N9S2
CAS number
2247544-02-9
Molecular weight
498.46
Formula
C18H21Cl2N9S2
Solubility
DMSO ： 7·35 mg/mL (14·75 mM; Need ultrasonic)
InChIKey
LJZUAAKUJAXXHQ-UHFFFAOYSA-N
Catalogue number
GC64975
Brand
GLPBIO
Computed properties PubChem CID 138319703 · TPSA 141 Ų · H-bond donors 1 · H-bond acceptors 9
TPSA
141 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
31

SMILES CC1=NC2=NC(=NN2C(=C1)SC3=NN=NN3CCN(C)C)SCC4=CC=C(C=C4)Cl.Cl

Computed descriptors from PubChem (CID 138319703), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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