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Chemical structure of MRTX-1257

GC64964

MRTX-1257

Also known as 2-[(2S)-4-[7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile

MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells

ChemicalCAS2206736-04-9MW565.71FormulaC33H39N7O2
CAS number
2206736-04-9
Molecular weight
565.71
Formula
C33H39N7O2
Solubility
DMSO ： 55 mg/mL (97·22 mM; Need ultrasonic)
InChIKey
YRYQLVCTQFBRLD-UIOOFZCWSA-N
Catalogue number
GC64964
Brand
GLPBIO
Computed properties PubChem CID 134326084 · XLogP 4.5 · TPSA 88.8 Ų · H-bond donors 0
XLogP
4.5
TPSA
88.8 Ų
H-bond donors
0
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
42

SMILES CC1=C2C(=CC=C1)C=CC=C2N3CCC4=C(C3)N=C(N=C4N5CCN([C@H](C5)CC#N)C(=O)C=C)OC[C@@H]6CCCN6C

Computed descriptors from PubChem (CID 134326084), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.