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Chemical structure of MRTX-1719

GC63558

MRTX-1719

Also known as 2-[4-[4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl]-1-methylpyrazol-5-yl]-4-chloro-6-cyclopropyloxy-3-fluorobenzonitrile

MRTX-1719 is a potent, selective inhibitor of the PRMT5, with an average IC50 20·4nM without MTA and 3·6nM with MTA present

ChemicalCAS2630904-45-7MW464.88FormulaC23H18ClFN6O2
CAS number
2630904-45-7
Molecular weight
464.88
Formula
C23H18ClFN6O2
InChIKey
BZKIOORWZAXIBA-UHFFFAOYSA-N
Catalogue number
GC63558
Brand
GLPBIO
Computed properties PubChem CID 156151242 · XLogP 2.7 · TPSA 118 Ų · H-bond donors 2
XLogP
2.7
TPSA
118 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
33

SMILES CN1C(=C(C=N1)C2=CC3=C(C=C2)C(=O)NN=C3CN)C4=C(C(=CC(=C4F)Cl)OC5CC5)C#N

Computed descriptors from PubChem (CID 156151242), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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