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Chemical structure of JAK/HDAC-IN-1

GC64959

JAK/HDAC-IN-1

Also known as 6-[4-[[5-chloro-4-(4-chloroanilino)pyrimidin-2-yl]amino]pyrazol-1-yl]-N-hydroxyhexanamide

JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines· JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively

ChemicalCAS2284621-75-4MW450.32FormulaC19H21Cl2N7O2
CAS number
2284621-75-4
Molecular weight
450.32
Formula
C19H21Cl2N7O2
Solubility
DMSO ： 20·83 mg/mL (46·26 mM; Need ultrasonic)
InChIKey
MTOQNLGMTJOJOF-UHFFFAOYSA-N
Catalogue number
GC64959
Brand
GLPBIO
Computed properties PubChem CID 138377596 · XLogP 3.3 · TPSA 117 Ų · H-bond donors 4
XLogP
3.3
TPSA
117 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
10
Heavy atoms
30

SMILES C1=CC(=CC=C1NC2=NC(=NC=C2Cl)NC3=CN(N=C3)CCCCCC(=O)NO)Cl

Computed descriptors from PubChem (CID 138377596), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.