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Chemical structure of JNJ-42253432

GC64822

JNJ-42253432

Also known as 2-methyl-N-[[1-(4-phenylpiperazin-1-yl)cyclohexyl]methyl]-3,4-dihydro-1H-isoquinoline-5-carboxamide

JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9·1 and 7·9 for rat and human P2X7 channels, respectively

ChemicalCAS1428327-35-8MW446.63FormulaC28H38N4O
CAS number
1428327-35-8
Molecular weight
446.63
Formula
C28H38N4O
InChIKey
DIKKTLPJDURHSW-UHFFFAOYSA-N
Catalogue number
GC64822
Brand
GLPBIO
Computed properties PubChem CID 71625847 · XLogP 4.3 · TPSA 38.8 Ų · H-bond donors 1
XLogP
4.3
TPSA
38.8 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
5
Heavy atoms
33

SMILES CN1CCC2=C(C1)C=CC=C2C(=O)NCC3(CCCCC3)N4CCN(CC4)C5=CC=CC=C5

Computed descriptors from PubChem (CID 71625847), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.