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Chemical structure of CSF1R-IN-3

GC64805

CSF1R-IN-3

Also known as N-[5-[(Z)-[6-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]-2-oxo-1H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-2-(4-methylpiperazin-1-yl)acetamide

CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2·1 nM)· CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells· CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity

ChemicalCAS2760584-90-3MW574.67FormulaC30H38N8O4
CAS number
2760584-90-3
Molecular weight
574.67
Formula
C30H38N8O4
InChIKey
YLKFFTVAKILRBN-STZFKDTASA-N
Catalogue number
GC64805
Brand
GLPBIO
Computed properties PubChem CID 162719835 · XLogP 2.6 · TPSA 148 Ų · H-bond donors 5
XLogP
2.6
TPSA
148 Ų
H-bond donors
5
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
42

SMILES CC1=C(NC(=C1NC(=O)CN2CCN(CC2)C)C)/C=C\3/C4=C(C=C(C=C4)NC(=O)NC5=NOC(=C5)C(C)(C)C)NC3=O

Computed descriptors from PubChem (CID 162719835), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.