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Chemical structure of TAK-653

GC64650

TAK-653

Also known as 9-(4-cyclohexyloxyphenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide

TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats

ChemicalCAS1358751-06-0MW373.47FormulaC19H23N3O3S
CAS number
1358751-06-0
Molecular weight
373.47
Formula
C19H23N3O3S
Solubility
DMSO ： ≥ 12·5 mg/mL (33·47 mM)
InChIKey
PXJBHEHFVQVDDS-UHFFFAOYSA-N
Catalogue number
GC64650
Brand
GLPBIO
Computed properties PubChem CID 56655833 · XLogP 2.7 · TPSA 79.7 Ų · H-bond donors 0
XLogP
2.7
TPSA
79.7 Ų
H-bond donors
0
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
26

SMILES CC1=CN2CCS(=O)(=O)N=C2C(=N1)C3=CC=C(C=C3)OC4CCCCC4

Computed descriptors from PubChem (CID 56655833), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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