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Chemical structure of ART812

GC64426

ART812

Also known as (2S,3S,4S)-N-(3-chloro-4-fluorophenyl)-3,4-dihydroxy-N-methyl-1-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-5-oxopyrrolidine-2-carboxamide

ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7·6 nM· ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ)

ChemicalCAS2607138-82-7MW461.79FormulaC19H16ClF4N3O4
CAS number
2607138-82-7
Molecular weight
461.79
Formula
C19H16ClF4N3O4
InChIKey
YJJOABOMFPGRED-JYJNAYRXSA-N
Catalogue number
GC64426
Brand
GLPBIO
Computed properties PubChem CID 156077039 · XLogP 2.8 · TPSA 94 Ų · H-bond donors 2
XLogP
2.8
TPSA
94 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
3
Heavy atoms
31

SMILES CC1=CC(=CC(=N1)N2[C@@H]([C@@H]([C@@H](C2=O)O)O)C(=O)N(C)C3=CC(=C(C=C3)F)Cl)C(F)(F)F

Computed descriptors from PubChem (CID 156077039), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.