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Chemical structure of OP-1074

GC64345

OP-1074

Also known as (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy]phenyl]-2H-chromen-7-ol

OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD), shows specific antiestrogenic activity for ERα and ERβ, inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC50 of 1·6 and 3·2?nM, respectively

ChemicalCAS1443752-76-8MW457.56FormulaC29H31NO4
CAS number
1443752-76-8
Molecular weight
457.56
Formula
C29H31NO4
InChIKey
KDVXAPCZVZMPMU-XBBWARJSSA-N
Catalogue number
GC64345
Brand
GLPBIO
Computed properties PubChem CID 71580998 · XLogP 5.3 · TPSA 62.2 Ų · H-bond donors 2
XLogP
5.3
TPSA
62.2 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
34

SMILES C[C@@H]1CCN(C1)CCOC2=CC=C(C=C2)[C@H]3C(=C(C4=C(O3)C=C(C=C4)O)C)C5=CC=C(C=C5)O

Computed descriptors from PubChem (CID 71580998), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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