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Chemical structure of ADH-6

GC64235

ADH-6

Also known as methyl 6-(3-aminopropoxy)-5-[[6-(3-aminopropoxy)-5-[(6-butoxy-5-nitropyridine-2-carbonyl)amino]pyridine-2-carbonyl]amino]pyridine-2-carboxylate

ADH-6 is a tripyridylamide compound· ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD· ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis· ADH-6 has the potential for the research of cancer diseases

ChemicalCAS2227429-65-2MW640.64FormulaC29H36N8O9
CAS number
2227429-65-2
Molecular weight
640.64
Formula
C29H36N8O9
InChIKey
KDVRSKDEDDWURT-UHFFFAOYSA-N
Catalogue number
GC64235
Brand
GLPBIO
Computed properties PubChem CID 135131858 · XLogP 2.1 · TPSA 249 Ų · H-bond donors 4
XLogP
2.1
TPSA
249 Ų
H-bond donors
4
H-bond acceptors
14
Rotatable bonds
18
Heavy atoms
46

SMILES CCCCOC1=C(C=CC(=N1)C(=O)NC2=C(N=C(C=C2)C(=O)NC3=C(N=C(C=C3)C(=O)OC)OCCCN)OCCCN)[N+](=O)[O-]

Computed descriptors from PubChem (CID 135131858), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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