GC64232
IRE1α kinase-IN-2
Also known as 1-[4-(8-amino-3-propan-2-ylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea
IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0·82 μM· IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3·12 μM)· IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines
ChemicalCAS1414938-21-8MW504.51FormulaC27H23F3N6O
- CAS number
- 1414938-21-8
- Molecular weight
- 504.51
- Formula
- C27H23F3N6O
- InChIKey
- MEJKZYOOTMLMBA-UHFFFAOYSA-N
- Catalogue number
- GC64232
- Brand
- GLPBIO
Computed properties PubChem CID 60196244 · XLogP 6 · TPSA 97.3 Ų · H-bond donors 3
- XLogP
- 6
- TPSA
- 97.3 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Rotatable bonds
- 4
- Heavy atoms
- 37
SMILES CC(C)C1=NC(=C2N1C=CN=C2N)C3=CC=C(C4=CC=CC=C43)NC(=O)NC5=CC=CC(=C5)C(F)(F)F
Computed descriptors from PubChem (CID 60196244), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il