Loading...
Chemical structure of IRE1α kinase-IN-1

GC63513

IRE1α kinase-IN-1

Also known as 3-(2-anilino-6-fluoro-1H-benzimidazol-5-yl)-6-chloro-N-[(1-methylpiperidin-4-yl)methyl]imidazo[1,2-b]pyridazin-8-amine

IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM

ChemicalCAS2328097-41-0MW504.99FormulaC26H26ClFN8
CAS number
2328097-41-0
Molecular weight
504.99
Formula
C26H26ClFN8
Solubility
DMSO ： 25 mg/mL (49·51 mM; ultrasonic and warming and heat to 60°C)
InChIKey
BPRAHARGXSNSSO-UHFFFAOYSA-N
Catalogue number
GC63513
Brand
GLPBIO
Computed properties PubChem CID 139593294 · XLogP 5.3 · TPSA 86.2 Ų · H-bond donors 3
XLogP
5.3
TPSA
86.2 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
36

SMILES CN1CCC(CC1)CNC2=CC(=NN3C2=NC=C3C4=CC5=C(C=C4F)NC(=N5)NC6=CC=CC=C6)Cl

Computed descriptors from PubChem (CID 139593294), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.