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Chemical structure of (R)-GSK-3685032

GC64210

(R)-GSK-3685032

Also known as (2R)-2-[[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethyl-2-pyridinyl]sulfanyl]-2-phenylacetamide

(R)-GSK-3685032 is the R-enantiomer of GSK-3685032· GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0·036 μM· GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition

ChemicalCAS2170140-50-6MW420.53FormulaC22H24N6OS
CAS number
2170140-50-6
Molecular weight
420.53
Formula
C22H24N6OS
Solubility
DMSO ： 60 mg/mL (142·68 mM; Need ultrasonic)
InChIKey
KNKHRZYILDZLRE-LJQANCHMSA-N
Catalogue number
GC64210
Brand
GLPBIO
Computed properties PubChem CID 132233544 · XLogP 2.6 · TPSA 158 Ų · H-bond donors 2
XLogP
2.6
TPSA
158 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
30

SMILES CCC1=C(C(=NC(=C1C#N)S[C@H](C2=CC=CC=C2)C(=O)N)N3CCC(CC3)N)C#N

Computed descriptors from PubChem (CID 132233544), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.