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Chemical structure of ALV2

GC63535

ALV2

Also known as 1-(3-chloro-4-methylphenyl)-3-[2-[3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]phenyl]propan-2-yl]urea

ALV2 is a potent and selective Helios degrader· ALV2 binds CRBN, with an IC50 of 0·57 μM· Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment

ChemicalCAS2438124-95-7MW523.97FormulaC26H26ClN5O5
CAS number
2438124-95-7
Molecular weight
523.97
Formula
C26H26ClN5O5
Solubility
DMSO ： 160 mg/mL (305·36 mM; Need ultrasonic)|Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
YKFHBIMJVFQOQL-UHFFFAOYSA-N
Catalogue number
GC63535
Brand
GLPBIO
Computed properties PubChem CID 146628167 · XLogP 2.5 · TPSA 137 Ų · H-bond donors 4
XLogP
2.5
TPSA
137 Ų
H-bond donors
4
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
37

SMILES CC1=C(C=C(C=C1)NC(=O)NC(C)(C)C2=CC(=CC=C2)NC3=CC(=O)N(C3=O)C4CCC(=O)NC4=O)Cl

Computed descriptors from PubChem (CID 146628167), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.