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Chemical structure of MMAE-d8

GC63461

MMAE-d8

Also known as (2S)-2,3,4,4,4-pentadeuterio-N-[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]-3-(trideuteriomethyl)butanamide

MMAE-d8 is a deuterated monomethyl auristatin E (MMAE) that can be used for the detection of MMAE

ChemicalCAS2070009-72-0MW726.03FormulaC39H59D8N5O7
CAS number
2070009-72-0
Molecular weight
726.03
Formula
C39H59D8N5O7
Solubility
DMSO : 100 mg/mL (137·74 mM; Need ultrasonic)
InChIKey
DASWEROEPLKSEI-CMHCZSPYSA-N
Catalogue number
GC63461
Brand
GLPBIO
Computed properties PubChem CID 78357789 · XLogP 4.1 · TPSA 150 Ų · H-bond donors 4
XLogP
4.1
TPSA
150 Ų
H-bond donors
4
H-bond acceptors
8
Rotatable bonds
20
Heavy atoms
51

SMILES [2H][C@@](C(=O)N(C)[C@@H]([C@@H](C)CC)[C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])NC(=O)[C@H](C(C)C)NC

Computed descriptors from PubChem (CID 78357789), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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