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Chemical structure of MMAF Hydrochloride

GC36633

MMAF Hydrochloride

Also known as (2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid;hydrochloride

MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent· MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A

ChemicalCAS1415246-68-2MW768.42FormulaC39H66ClN5O8
CAS number
1415246-68-2
Molecular weight
768.42
Formula
C39H66ClN5O8
Solubility
DMSO： 27 mg/mL (35·14 mM and warming)
InChIKey
BUPKFQQDMNUXOY-KMYLZLQDSA-N
Catalogue number
GC36633
Brand
GLPBIO
Computed properties PubChem CID 78357791 · TPSA 167 Ų · H-bond donors 5 · H-bond acceptors 9
TPSA
167 Ų
H-bond donors
5
H-bond acceptors
9
Rotatable bonds
21
Heavy atoms
53

SMILES CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC.Cl

Computed descriptors from PubChem (CID 78357791), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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