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Chemical structure of Icenticaftor

GC63353

Icenticaftor

Also known as 3-amino-6-methoxy-N-[(2S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl]-5-(trifluoromethyl)pyridine-2-carboxamide

Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC50s of 79 nM and 497 nM for F508del and G551D CFTR, respectively

ChemicalCAS1334546-77-8MW361.24FormulaC12H13F6N3O3
CAS number
1334546-77-8
Molecular weight
361.24
Formula
C12H13F6N3O3
Solubility
DMSO ： 150 mg/mL (415·24 mM; ultrasonic and warming and heat to 60°C)
InChIKey
USHQRIKZLHNPQR-JTQLQIEISA-N
Catalogue number
GC63353
Brand
GLPBIO
Computed properties PubChem CID 58442344 · XLogP 2.2 · TPSA 97.5 Ų · H-bond donors 3
XLogP
2.2
TPSA
97.5 Ų
H-bond donors
3
H-bond acceptors
11
Rotatable bonds
4
Heavy atoms
24

SMILES C[C@](CNC(=O)C1=C(C=C(C(=N1)OC)C(F)(F)F)N)(C(F)(F)F)O

Computed descriptors from PubChem (CID 58442344), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.