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Chemical structure of Darigabat

GC63145

Darigabat

Also listed as PF-06372865

PF-06372865 is an orally active, α2/α3/α5 subtype-selective GABAA positive allosteric modulator (PAM)

ChemicalCAS1614245-70-3MW440.49FormulaC22H21FN4O3S
CAS number
1614245-70-3
Molecular weight
440.49
Formula
C22H21FN4O3S
Solubility
DMSO ： 50 mg/mL (113·51 mM; Need ultrasonic)
InChIKey
PTTQXDBPTFOCMT-UHFFFAOYSA-N
Catalogue number
GC63145
Brand
GLPBIO
Computed properties PubChem CID 76287260 · XLogP 2.9 · TPSA 95.4 Ų · H-bond donors 0
XLogP
2.9
TPSA
95.4 Ų
H-bond donors
0
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
31

SMILES CCN1C=NC2=C1N=NC=C2C3=CC(=C(C=C3)F)C4=C(C=C(C=C4)S(=O)(=O)CC)OC

Computed descriptors from PubChem (CID 76287260), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.