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Chemical structure of NVS-SM2

GC63123

NVS-SM2

Also known as 2-[6-[methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)phenol

NVS-SM2 is a potent, orally active and brain-penetrant SMN2 splicing enhancer with an EC50 of 2 nM for SMN

ChemicalCAS1562333-92-9MW406.52FormulaC23H30N6O
CAS number
1562333-92-9
Molecular weight
406.52
Formula
C23H30N6O
Solubility
DMSO ： 75 mg/mL (184·49 mM; Need ultrasonic)
InChIKey
XSBJQWNBBMWICJ-UHFFFAOYSA-N
Catalogue number
GC63123
Brand
GLPBIO
Computed properties PubChem CID 136598218 · XLogP 2.9 · TPSA 90 Ų · H-bond donors 3
XLogP
2.9
TPSA
90 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
30

SMILES CC1(CC(CC(N1)(C)C)N(C)C2=NN=C(C=C2)C3=C(C=C(C=C3)C4=CNN=C4)O)C

Computed descriptors from PubChem (CID 136598218), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.