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Chemical structure of AR453588

GC62846

AR453588

Also known as 1-[4-[5-[[3-[(2-methyl-3-pyridinyl)oxy]-5-pyridin-2-ylsulfanyl-2-pyridinyl]amino]-1,2,4-thiadiazol-3-yl]piperidin-1-yl]ethanone

AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM

ChemicalCAS1065609-00-8MW519.64FormulaC25H25N7O2S2
CAS number
1065609-00-8
Molecular weight
519.64
Formula
C25H25N7O2S2
Solubility
DMSO ： 100 mg/mL (192·44 mM; Need ultrasonic)
InChIKey
WITGITFYEMHCEZ-UHFFFAOYSA-N
Catalogue number
GC62846
Brand
GLPBIO
Computed properties PubChem CID 59291641 · XLogP 4.2 · TPSA 160 Ų · H-bond donors 1
XLogP
4.2
TPSA
160 Ų
H-bond donors
1
H-bond acceptors
10
Rotatable bonds
7
Heavy atoms
36

SMILES CC1=C(C=CC=N1)OC2=C(N=CC(=C2)SC3=CC=CC=N3)NC4=NC(=NS4)C5CCN(CC5)C(=O)C

Computed descriptors from PubChem (CID 59291641), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.